results treatments through mirnas can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. conclusions further work is needed to be done to make mirna treatments available to large number of people suffering from various bone diseases. context mirnas can regulate the expression of genes by interfering in their mrnas, acting as key regulators of diverse cell...

objectives : bone remodeling occurs during orthodontic treatment; this process enables tooth movement. many factors can affect bone remodeling at the cellular level, such as nutritional supplements that can affect tooth movement. the present study was designed to evaluate the effect of dietary vitamin c on orthodontic tooth movement in rats.  materials and methods: this study was carried out on...

Bone is a dynamic organ that, once formed, undergoes constant remodeling process that includes bone resorption and synthesis. Osteoclasts osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed XBP1 plays vital role metabolism, includ...

Bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain function. involves the synchronized differentiation activity bone-related cell types including matrix-depositing osteoblasts, matrix-resorbing osteoclasts, collagen/extracellular matrix-producing chondrocytes, progenitors these types. T B cells are adaptive immune that can i...

A finite element-based bone remodeling study in human was conducted in the lumbar spine. This was done to examine the validity of the bone remodeling algorithm by comparing to experimental data. A non-linear 3-D finite element model of the normal ligamentous lumbar spine of L3 to L5 was generated. Two different material configurations were assigned to the finite element model. Two analyses with...

The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit. After the attainment of peak bone mass, bone remodeling is balanced and bone mass is stable for one or two decades until age-related bone loss begins. Age-related bone loss is caused by increases in resorptive activity an...

The process of bone remodeling is regulated by metabolic activities of many bone cells. While osteoclasts and osteoblasts are responsible for bone resorption and formation, respectively, activities of these cells are believed to be controlled by a mechanosensory system of osteocytes embedded in the extracellular bone matrix. Several experimental and theoretical studies have suggested that the s...

increased duration of fixed orthodontic treatments leads to increased tooth root degeneration, gum inflammation and tooth caries. to decrease the time period of orthodontic treatment, it is essential to facilitate tooth movement or in other words increase the speed of bone remodeling. use of low level laser therapy is a method for achieving this goal.